<![CDATA[Background: Diabetes mellitus is a chronic metabolic disease that requires lifelong treatment. Medication adherence plays an important role in achieving optimal glycemic control and preventing complications. Knowledge and family support are considered factors that may influence medication adherence. Objective: To determine the relationship between knowledge about diabetes mellitus and family support with medication adherence among patients with type 2 diabetes mellitus at RI Sidomulyo Public Health Center, Pekanbaru City, in 2026. Methods: This analytic observational study employed a cross-sectional design involving 40 respondents selected through accidental sampling. Data were collected using the Diabetes Knowledge Questionnaire (DKQ-24), Hensarling Diabetes Family Support Scale (HDFSS), and Medication Adherence Report Scale (MARS-5). Data were analyzed using the Fisher exact test with a significance level of 95% (α = 0.05). Results: Most respondents had fair to poor knowledge (77.5%), fair to poor family support (55.0%), and high medication adherence (85.0%). Statistical analysis showed no significant relationship between knowledge and medication adherence (p = 0.115) or between family support and medication adherence (p = 0.673). Conclusion: Knowledge about diabetes mellitus and family support were not significantly associated with medication adherence among patients with type 2 diabetes mellitus.]]>
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