Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE)
Vol. 5 No. 2 (2026): Agustus: Jurnal Riset Rumpun Ilmu Kedokteran

Uji Efektivitas Anxiolytic Ekstrak Teh Hijau (Camellia Sinensis) terhadap Tikus Model Kecemasan Dengan Metode Elevated Plus Maze

M. Fiqri Maulana Harahap (Unknown)
Ilham Hariaji (Unknown)



Article Info

Publish Date
27 Aug 2026

Abstract

Introduction: Green tea (Camellia sinensis) is known for its anxiolytic benefits derived from L-theanine, EGCG, and caffeine, which influence neurotransmitters like GABA and dopamine and enhance alpha brain wave activity. Methods: This experimental study employed a post-test only with control group design. The subjects were 27 male Wistar rats induced with anxiety using the Forced Swim Test. Treatment was administered with green tea extract at a dose of 3.6 mg/kgBW. Anxiety levels were measured using the Elevated Plus Maze (EPM) method, focusing on the duration spent in open arms. Statistical analysis was conducted using One-Way ANOVA, followed by post-hoc Tukey tests to identify significant differences between groups. Results: The treatment group showed an average time in open arms of 114.22 seconds, approaching the positive control (fluoxetine ) at 117.67 seconds, and higher than the negative control (Placebo) at 90.33 seconds. Statistical analysis indicated significant differences among treatment groups (p < 0.001). Conclusion: Green tea extract demonstrated significant anxiolytic effects in reducing anxiety in a rat model.

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Journal Info

Abbrev

JURRIKE

Publisher

Subject

Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

Description

Jurnal Riset Rumpun Ilmu Kedokteran adalah jurnal yang ditujukan untuk publikasi artikel ilmiah yang diterbitkan oleh Pusat riset dan Inovasi Nasional, Universitas Sains dan Teknologi Komputer. Jurnal ini adalah jurnal Riset Rumpun Ilmu Kedokteran yang bersifat peer-review dan terbuka. Bidang kajian ...