<![CDATA[Rhodomyrtus tomentosa (Karamunting) is an evergreen shrub of the Myrtaceae family traditionally used in South and Southeast Asia for treating diarrhea, dysentery, gynecological disorders, and wounds. Recent studies have identified diverse metabolites, especially triterpenoids, flavonoids, phenolics, and meroterpenoids, with rhodomyrtone as a key antibacterial compound. A review of 128 studies (2014–2024) shows that extracts and isolated compounds of Rhodomyrtus tomentosa exhibit strong antioxidant, antimicrobial, anti-inflammatory, and anticancer activities. Major bioactive compounds include rhodomyrtone, myricetin, gallic acid, ellagic acid, and piceatannol. Acute toxicity tests indicate safety up to 3,000 mg/kg BW, though nanoformulations may increase toxicity. Novel mechanisms, such as membrane protein trapping and antibiofilm effects, suggest potential against multidrug-resistant pathogens. Despite gaps in long-term toxicity and clinical data, Rhodomyrtus tomentosa holds promise as a source of new therapeutic agents. Keywords: Rhodomyrtus tomentosa; Karamunting; Bioactive compounds; Pharmacological activities; Antimicrobial.]]>
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