Introduction: Fatigue is a frequent and disabling symptom among patients receiving hemodialysis. Progressive muscle relaxation (PMR) may be incorporated into nursing care as a simple non-pharmacological strategy; however, individual responses during a brief intradialytic intervention require cautious interpretation. Methods: This descriptive multiple-case study involved three patients with chronic kidney disease receiving hemodialysis who had a nursing diagnosis of fatigue and baseline Fatigue Assessment Scale (FAS) scores of 35 or higher. Guided PMR was administered during three hemodialysis sessions. FAS scores were recorded before the intervention, at the second session, and after the third session, then analyzed descriptively for each patient. Results: FAS scores decreased from 38 to 35 and 30 in Mr. W, from 39 to 36 and 31 in Mr. E, and from 41 to 38 and 34 in Mrs. M. The total reductions were 8, 8, and 7 points, respectively. All patients moved from the extreme-fatigue range (FAS 35-50) to the substantial-fatigue range (FAS 22-34). Mrs. M had the highest final score and the lowest recorded hemoglobin level (8.6 g/dL). Conclusion: A gradual reduction in fatigue scores was observed in all three patients after the short series of PMR sessions. These observations support PMR as a feasible adjunct to fatigue management during hemodialysis, but they do not establish causality. Clinical contributors, particularly anemia and other dialysis-related factors, should be assessed concurrently.
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