<![CDATA[Background: Breast cancer remains a major global and national health burden. Immunohistochemistry (IHC) markers including estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) combined with histopathological grading, are essential for determining molecular subtypes and guiding targeted therapy. Purpose: This study aims to evaluate the profile of IHC molecular subtypes and histopathological grades in breast carcinoma patients at Jakarta Islamic Hospital from May 2021 to May 2025. Methods: A descriptive cross-sectional study was conducted using retrospective secondary data from medical records of breast carcinoma patients who underwent IHC examination during the specified period. Results: A total of 96 breast carcinoma cases were analyzed. Invasive Breast Carcinoma of No Special Type (NST) was the most frequent histopathological type (82.3%), with histopathological grade II being the most common. Luminal A was the predominant molecular subtype across all grades and nearly all age groups, peaking in patients aged 40–49 years. Conversely, Triple-Negative and HER2-positive subtypes were more frequently associated with higher histopathological grades (grades II and III). Conclusion: Invasive breast carcinoma NST, grade II, and the Luminal A subtype are the most prevalent clinical presentations at Jakarta Islamic Hospital, with aggressive subtypes correlating with higher histological grades.]]>
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