Objectives: This study aimed to analyze the differences in maxillary sinus volume measurements between the linear dimension method and the semi-automatic segmentation method using CBCT images. Maxillary sinus volume is an important anatomical parameter that reflects variations in sinus morphology and pneumatization and may support clinical assessment and treatment planning. Materials and Methods: This comparative analytical study used secondary CBCT radiographic data of patients aged 20–40 years from the Radiology Unit of RSGM FKG USAKTI. A total of 50 samples, or 100 maxillary sinuses, were analyzed using two measurement methods, namely the linear dimension method and the semi-automatic segmentation method. Results: The mean maxillary sinus volume measured using the linear dimension method was 24,501.85 mm³ on the right side and 25,004.67 mm³ on the left side. In contrast, measurements obtained using the semi-automated segmentation method yielded mean volumes of 17,720.65 mm³ for the right maxillary sinus and 18,455.25 mm³ for the left maxillary sinus. The paired t-test demonstrated mean differences of 8,325.4 mm³ on the right side and 10,701 mm³ on the left side between the two measurement methods. These results indicate a difference between maxillary sinus volume measurements obtained using the linear dimension method and the semi-automatic segmentation method. Conclusion: Volume measurements obtained using the semi-automatic segmentation method are closer to the average normal maxillary sinus volume
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