<![CDATA[The shift toward sustainable practices in chemical manufacturing necessitates the replacement of traditional solvents with safer, environmentally benign alternatives. This study proposes a dual-criteria evaluation framework that integrates Safety, Health, and Environmental (SHE) scores with REACH regulatory compliance to support green solvent selection. Using a curated dataset of solvents characterized by physical and operational risk metrics, the methodology identifies high-performing green solvents suitable for sustainable process design. Quantitative assessments were performed based on SHE scores (scale 1–10), flash point, boiling point, and regulatory status. Correlation analysis revealed key relationships between solvent physical properties and SHE risk indicators. Recommended solvents were further evaluated for practical applications in extraction, synthesis, and purification processes. Solvents such as ethanol, water, and propylene carbonate demonstrated favorable SHE profiles and full REACH compliance. Results confirmed the utility of simple scoring systems in streamlining solvent substitution while ensuring safety and regulatory alignment. The framework offers a transparent, efficient method for solvent screening, serving as a foundation for broader sustainability tools like Process Mass Intensity (PMI), E-Factor, and Life Cycle Assessment (LCA). This model enhances industrial decision-making by enabling safer and more sustainable solvent use. Its adaptability supports both laboratory-scale and industrial applications, promoting compliance and long-term environmental stewardship.]]>
Copyrights © 2025
