Highlights: Using masks every day, especially during the COVID-19 pandemic, can affect the condition of the facial skin. Risk factors for mask use can cause AV. Abstract Introduction: Wearing masks reduces hand-to-face contact and inhalation of respiratory pathogens, thereby reducing coronavirus disease 2019 (COVID-19) transmission. However, acne vulgaris (AV) or maskne often develops in mask-covered areas. This study examined the correlation between mask use and AV among healthcare workers at Dr. M. Haulussy Regional Hospital, Ambon, Indonesia, in 2022. Methods: This study was conducted with a quantitative analytical design with a cross-sectional approach. The sampling technique used was a combination of stratified and consecutive sampling. The sample in this study comprised 178 people, including doctors (15.7%) and nurses (84.3%). Data analysis was processed using the International Business Machines Corporation (IBM) Statistical Package for the Social Sciences (SPSS) version 25.0. Results: This study found more respondents used surgical masks (75.3%) than N95 (24.7%). Chi-square analysis showed AV correlated with mask-wearing duration (p=0.011) and frequency of mask changes (p=0.038), but not with mask type (p=0.997). Conclusion: This study showed maskne was common among healthcare workers, mostly affecting the O-zone. No relationship was found between mask type and acne, whereas significant associations were observed with mask-wearing duration and the frequency of mask changes.
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