<![CDATA[Background: Self-medication using over-the-counter medicines continues to grow in Indonesia, reaching 69.43% in 2022. Children's cough medicine advertising in mass media is considered one of the factors influencing selfmedication decisions; however, persuasive advertising may promote irrational drug selection and contribute to medication errors. Objective: This study aimed to determine the influence of knowledge regarding children's cough medicine advertising in mass media on community self-medication behavior at Dahlia 3 Posyandu, Pucang Sawit Village, Surakarta City. Method: This study is a descriptive-analytical study using an analytical cross-sectional survey design with accidental sampling, involving 42 mothers who participated in posyandu activities in January 2025. A validated questionnaire was used, tested for reliability using KR-20 for knowledge (α = 0.809) and Cronbach's Alpha for behavior (α = 0.734). Results: Univariate analysis showed that most respondents had good knowledge (90.5%) and negative self-medication behavior (57.1%). Normality testing using KolmogorovSmirnov and Shapiro-Wilk indicated non-normal data distribution (p = 0.000), thus the median was used as the cut-off point. Fisher's Exact Test revealed no significant relationship between knowledge and self-medication behavior (p = 0.623). Conclusion: Knowledge of children's cough medicine advertising does not directly determine self-medication behavior, as behavior is shaped by multiple interacting factors including attitudes, personal experience, social influence, and advertising persuasiveness.]]>
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