<![CDATA[Background: Peri-implantitis is an infectious disease characterized by peri-implant tissue inflammation and bone loss, adversely affecting oral health and wellbeing. Mechanical debridement is the primary treatment, but adjunctive therapies may enhance its effectiveness. This study aimed to evaluate the efficacy of systemic folic acid supplementation as an adjunct to mechanical debridement in the management of peri-implantitis, focusing on clinical outcomes and the modulation of peri-implant crevicular fluid (PICF) interleukin-6 (IL-6) levels. Purpose: This study aims to assess the clinical and biochemical effects of systemic folic acid supplementation when used alongside mechanical debridement in the treatment of peri-implantitis. Methods: This prospective clinical study was conducted at Saveetha Dental College, enrolling systemically healthy participants diagnosed with peri-implantitis (n = 50). Study participants were assigned to receive either mechanical debridement with placebo (control; n = 25) or with folic acid supplementation (test; n = 25). The plaque index (PI), gingival index (GI), pre-implant probing depth (PPD), clinical attachment level (CAL), and IL-6 levels in PICF were measured at baseline and at 3 months. Statistical analysis was performed using paired and independent t-tests. Results: Significant improvement was observed in both groups from baseline to 3 months in all parameters (p < 0.05). However, greater improvements in PI, GI, PPD, CAL, and IL-6 levels were noted in the test group than in the control group (p < 0.05). Conclusion: Systemic folic acid supplementation greatly improves the therapeutic benefits of mechanical debridement in peri-implantitis treatment, leading to better clinical and biochemical outcomes.]]>
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