Role of Interleukin-10 Promoter Gene Polymorphisms in Susceptibility to Systemic Lupus Erythematosus: Systematic Review

Desi Oktariana (Department of Clinical Pathology, Department of Biomedical Science, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia)
Ade Rizki Putri Ratih (Master of Biomedical Science Program, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia)
Phey Liana (Department of Clinical Pathology, Department of Biomedical Science, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia)
Kemas Ya’kub Rahadiyanto (Department of Clinical Pathology, Department of Biomedical Science, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia)
Ririn Eviningtyas (Department of Clinical Pathology, Department of Biomedical Science, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia)
Gita Dwi Prasasty (Department of Parasitology, Department of Biomedical Science, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia)
Yuniza Yuniza (Department of Internal Medicine, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia)
Hafizzanovian Hafizzanovian (Department of Internal Medicine, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia)
Aseptianova Aseptianova (Department of Biology Education, Faculty of Teacher Training and Education, Universitas Muhammadiyah Palembang, Palembang, Indonesia)

Eksakta : Berkala Ilmiah Bidang MIPA
Vol. 27 No. 04 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) In Progress

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem inflammation that predominantly affects women of reproductive age. Genetic factors, particularly polymorphisms within the interleukin-10 (IL-10) promoter region, have been implicated in disease susceptibility through their influence on cytokine expression and immune regulation. This systematic review aimed to evaluate the association between IL-10 promoter polymorphisms and SLE susceptibility across different populations. A systematic literature search was conducted according to PRISMA guidelines using Google Scholar, PubMed, ScienceDirect, SagePub, and Wiley Online Library for studies published between 2005 and 2025. Eligible case-control studies investigating IL-10 promoter polymorphisms in SLE were included. Of 82 records identified, 12 studies met the eligibility criteria, comprising 2,462 patients with SLE and 3,274 healthy controls. Most studies reported significant associations between SLE susceptibility and the IL-10 promoter polymorphisms −1082A/G, −819C/T, and −592C/A. The GCC haplotype was the most consistently reported risk haplotype and was frequently associated with increased IL-10 expression and greater susceptibility to SLE. Overall, current evidence supports the contribution of IL-10 promoter polymorphisms to genetic susceptibility to SLE across diverse populations.