<![CDATA[Potential drug–drug interactions (pDDIs) are a major cause of medication-related problems in critically ill patients; however, evidence from intensive care units (ICUs) in Indonesia remains limited. This prospective cross-sectional study aimed to evaluate the prevalence, severity, and predictors of pDDIs among 100 patients admitted to the ICU of Kendal Islamic Hospital, Central Java, Indonesia, from June to July 2025. Medication data were extracted from electronic medical records and systematically screened using the DrugBank® database. Descriptive analysis, chi-square test, and binary logistic regression were performed. All patients experienced at least one pDDI, with a total of 4,938 pDDIs involving 50 distinct drug pairs. Moderate-severity interactions predominated (66.5%), followed by minor (23.4%) and major (10.1%) interactions, with the severity distribution differing significantly (χ² = 2,577.38; p < 0.001). Fentanyl–ranitidine was the most frequently identified drug pair. Binary logistic regression identified age category as the only independent predictor of major pDDIs (OR = 3.531; 95% CI 1.564–7.975; p = 0.003), whereas sex and ICU length of stay were not significantly associated. These findings demonstrate the high burden of pDDIs among ICU patients and highlight the need for systematic pDDI screening and greater involvement of clinical pharmacists to improve medication safety.]]>
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