Journal of Pharmaceutical and Sciences.
JPS Volume 9 Nomor 3 (2026)

Formulasi Krim Ekstrak Etanol Buah Bit (Beta vulgaris L.) sebagai Antioksidan

Rima Sri Nurbayanti (Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Advent Indonesia, Jawa Barat, Indonesia)
Marvel Reuben Suwitono (Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Advent Indonesia, Jawa Barat, Indonesia)
Titin Sulastri (Program Studi Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Advent Indonesia, Jawa Barat, Indonesia)



Article Info

Publish Date
22 Aug 2026

Abstract

The skin is highly susceptible to free radical damage, including exposure to ultraviolet rays, which can trigger premature aging. Beets (Beta vulgaris L.) are known to contain secondary metabolites such as flavonoids, tannins, saponins, and alkaloids that exhibit antioxidant activity. This study aims to develop a physically stable cream formulation from beetroot ethanol extract that possesses antioxidant activity. The extraction method used in this study was maceration. The resulting concentrated extract was then formulated into an oil-in-water (O/W) cream base with varying extract concentrations (5%, 10%, and 15%). This study aimed to evaluate the physical stability of the creams, including organoleptic properties, pH, homogeneity, viscosity, spreadability, tackiness, and antioxidant activity using the DPPH (2,2-diphenyl-2-picrylhydrazyl) method. All formulations were homogeneous, with a pH of 5–6, viscosity of 3,537–3,544 cps, spreadability in the range of 5–7 cm, and adhesion time of 2.12–2.41 seconds. The IC50 value for pure beetroot extract was 190.50 ppm ((IC50 151-200 ppm weak), F1 cream (5%) at 732.85 ppm, F2 (10%) at 686.97 ppm, and F3 (15%) at 632.38 ppm (IC50 >200 ppm very weak). It can be concluded that beet fruit extract can be formulated into a physically stable cream preparation, even though its antioxidant activity is classified as very weak

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Journal Info

Abbrev

jps

Publisher

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

Description

Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, ...