Current advances based-chitosan-hydroxyapatite nanocomposite and PRF-hydroxyapatite bone graft for alveolar and maxillofacial bone regenaration : Perkembangan terkini nanokomposit kitosan-hidroksiapatit dan bone graft PRF-hidroksiapatit untuk regenerasi tulang alveolar dan maksilofasial

Muhammad Irfan Rasul (Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia)
Tyas Nadya Wahdaniah (Clinical Student, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia)
Sri Putri Marhaeni (Clinical Student, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia)
Husnul Khotimah (Clinical Student, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia)

MDJ (Makassar Dental Journal)
Vol. 15 No. 2 (2026): Volume 15 Issue 2 August 2026

Maxillofacial bone loss commonly occurs due to congenital disorders, tumors, trauma, and inflammatory processes, including alveolar bone loss resulting from periodontitis, endodontic pathology, and tooth extraction. Following extraction, a significant reduction in alveolar ridge height and width occurs. Autologous bone grafting remains the gold standard for bone regeneration; however, it is limited by donor site availability and associated complication risks. Biomaterials have been developed as alternatives, including chitosan–hydroxyapatite nanocomposites, which are biocompatible and osteoconductive, and platelet-rich fibrin, which is rich in growth factors supporting osteogenesis and tissue healing. This literature review aims to compare the effectiveness of both biomaterials in alveolar bone regeneration and maxillofacial reconstruction.