The Relationship Between Interleukin-1β Levels and Visual Analog Scale Value in Preeclampsia Patients Who Received Perioperative C-Sectional Parecoxib With Spinal Anesthesia

Dino Irawan (Department of Anesthesiology and Critical Care, Faculty of Medicine, Riau University, Riau|Riau University, Riau)
Yusrawati Yusrawati (Department of Obstetrics and Gynecology, Faculty of Medicine, Andalas University, Padang|Andalas University, Padang)
Fidel Ganis Siregar (Department of Obstetrics and Gynecology, Faculty of Medicine, Sumatera Utara University, Medan|Sumatera Utara University, Medan)
Dewi Yulianti Bisri (Department of Anesthesiology and Critical Care, Faculty of Medicine, Padjadjaran University, Bandung|Padjadjaran University, Bandung)

Jurnal Anestesiologi Indonesia
Vol 16, No 2 (2024): JAI (Jurnal Anestesiologi Indonesia)

Background: Interleukin1β (IL-1β) increases during inflammation and functions as a mediator that terminates endothelial dysfunction and regulates cellular apoptosis in preeclampsia. Parecoxib is a potential agent because of its superiority as an analgesic and anti-inflammatory that can work peripherally and centrally, with minimal side effects on the mother and baby.Objective: This study aimed to determine the relationship between IL-1β levels and visual analog scale (VAS) scores in preeclampsia patients who received parecoxib perioperatively for cesarean section with spinal anesthesia.Methods: Non-experimental cross-sectional research on preeclampsia patients who received perioperative parecoxib and underwent cesarean section with spinal anesthesia as many as 18 people at Arifin Ahmad Hospital, Riau Province, and Bina Kasih Hospital, Pekanbaru. Samples were taken by Consecutive Sampling.Result: There was a moderate negative correlation between IL-1β and VAS (p <0.05; correlation coefficient -0.487).Conclusion: In preeclampsia patients who received parecoxib following a 24-hour spinal anesthetic cesarean surgery, there is a correlation between IL-1β levels and VAS scores.