<![CDATA[Introduction: Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. It remains a global health problem with high mortality. This study aims to analyze the mortality profile of patients diagnosed with sepsis in the internal medicine ward of Dr. Soetomo General Academic Hospital throughout 2022. Methods: This descriptive retrospective study evaluated medical records of deceased sepsis patients (SOFA score ≥2) in 2022. Analyzed variables included demographic data, comorbidities, infection sources, culture results, and SOFA scores. Out of 718 sepsis deaths, 88 met the criteria for detailed analysis. Results: Most non-survivors were male (53.0%), elderly (≥60 years, 44.3%), and had a normal BMI (67.0%). The primary comorbidities were diabetes mellitus (43.2%) and hypertension (38.6%). Pulmonary infection was the main source (43.2%), with urine (33%) and blood (27%) yielding the most positive cultures. Escherichia coli (14.8%) and Klebsiella pneumoniae (12.5%) were the dominant pathogens. Initial SOFA scores mostly ranged between 2–9 (92.0%, median 5). While individual SOFA scores for respiratory, coagulation, hepatic, cardiovascular, and neurological systems were predominantly 0, renal dysfunction uniquely presented with severe failure (SOFA score 4 in 26.1%). Conclusion: The mortality rate for sepsis patients in the internal medicine ward of Dr. Soetomo General Academic Hospital showed a reduction in 2022 compared to the previous year. However, renal dysfunction was identified as a significant factor contributing to mortality, indicated by elevated renal SOFA scores. Further research comparing survivors and non-survivors is essential to identify factors influencing outcomes.]]>
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