Background: Coronary no-reflow is characterized by very slow or absent epicardial blood flow. It results in inadequate myocardial perfusion and is an independent predictor of mortality due to malignant arrhythmias and heart failure. Case Illustration: This case describes a patient who underwent angiography due to a reperfused inferior myocardial infarction. Following the diagnostic procedure, a decision was made to perform a primary percutaneous intervention on the Circumflex (Cx) artery. When the stent balloon was inflated to the optimal pressure, it burst. The control image revealed the development of no-reflow after the Left Main Coronary Artery (LMCA). This potentially fatal condition was successfully treated with the administration of Intracoronary (IC) adrenaline. Conclusion: No-reflow is a significant factor affecting mortality. The occurrence of this phenomenon in multiple vessels further increases this risk, but it can be effectively managed with IC adrenaline, and multiple-vessel no-reflow can be treated.
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