Antihypertensive Jamu Supplementation Improves Blood Pressure and Renal Oxidative Stress Markers in Fructose-Fed Rats

Sri Teguh Rahayu (Department of Pharmacy, Faculty of Health Sciences, Universitas Esa Unggul, West Jakarta 11510, Jakarta, Indonesia)
Aprilita Rina Yanti Eff (Department of Pharmacy, Faculty of Health Sciences, Universitas Esa Unggul, West Jakarta 11510, Jakarta, Indonesia)
Yonatan Eden (Department of Pharmacy, Faculty of Health Sciences, Universitas Esa Unggul, West Jakarta 11510, Jakarta, Indonesia)
Anna Yuliana (Department of Pharmacy, Faculty of Health Sciences, Universitas Esa Unggul, West Jakarta 11510, Jakarta, Indonesia)

Indonesian Journal of Jamu
Vol. 11 No. 5 (2026): Jurnal Jamu Indonesia (In Progress)

High fructose consumption induces hypertension and renal oxidative stress, and herbal supplements (jamu) are potential agents for reversing this damage. This study examined the antihypertensive and antioxidant activity of a jamu formulation by measuring blood pressure and renal superoxide dismutase (SOD), glutathione (GSH), and malondialdehyde (MDA) levels in fructose-induced rats. Thirty Sprague-Dawley rats were divided into six groups: jamu at 0.01 (A1), 0.02 (A2), and 0.03 g/kg body weight (BW) (A3); captopril as the positive control (PC); negative control (NC); and normal control (SC). Rats received 10% fructose for 8 weeks to induce hypertension, continuing concurrently during the 2-week treatment period (weeks 9–10). Jamu supplementation significantly reduced blood pressure and MDA levels and increased SOD activity and GSH levels compared with the NC group (p < 0.05). Two weeks of jamu administration exerted antihypertensive and antioxidant effects, improving blood pressure control and renal oxidative stress markers in fructose-fed rats.