The aims of this study was to build a SEIR model on Covid-19 transmission, to find out the analysis and simulation of the SEIR mathematical model for the prevention of Covid-19 transmission and to determine the effectiveness of the application of the 3M health protocol recovered Covid-19 from January 2021 to April 2021. The results shown that the SEIR model can be used to prevent transmission of Covid-19. The results of the analysis of the SEIR model shown that the basic reproduction number 푹ퟎ<1for the three simulations with the presentation of the application of the 3M health protocol were 10%, 50% and 90%, respectively. Meanwhile, the simulation results of the model shown that the higher the 3M application presentation, the smaller the value of the basic reproduction number. This shown that the implementation of the 3M health protocol against Covid-19transmission in Makassar City is effective, because it is able to minimize the rate of increase in the number of Covid-19 cases. This can be a reference for the Makassar City Government so that the application of 3M continues to be carried out to break the chain ofCovid-19spreadingin Makassar.
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