<![CDATA[Introduction : Polycystic ovary syndrome (PCOS) is a prevalent polygenic endocrine disorder affecting women during their reproductive years. It is marked by excessive androgen levels, irregular ovulation, and the presence of multiple ovarian follicles. The CYP17A1 gene has been implicated in androgen overproduction, yet the extent to which CYP17A1 genetic variants influence the susceptibility to PCOS is still uncertain. The following section summarizes studies that have examined the link between the CYP17A1 rs743572 polymorphism and PCOS risk in women of reproductive age. Method: A thorough literature search was performed across three databases: SCOPUS, ScienceDirect, and PubMed, to identify studies meeting the inclusion criteria. The risk of bias for the included studies was evaluated using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist. Collected data were subsequently analyzed using RevMan version 5.4. Result: Four studies involving 1,542 PCOS cases and 1,438 controls were included in the meta-analysis. CYP17A1 (rs743572) polymorphism was significantly associated with increased PCOS risk across all genetic models: allele model (OR = 1.39, 95% CI: 1.09-1.76, P = 0.007, I² = 51%), dominant model (OR = 1.53, 95% CI: 1.10-2.11, P = 0.01, I² = 43%), and recessive model (OR = 1.52, 95% CI: 1.10-2.10, P = 0.01, I² = 9%), indicating consistent positive associations with low to moderate heterogeneity. Conclusion: The CYP17 T/C (rs74357) polymorphism is a significant factor contributing to heightened susceptibility to polycystic ovary syndrome in individuals carrying the C allele. These findings indicate that CYP17 gene polymorphisms could serve as a potential risk factor for developing polycystic ovary syndrome, or may play an important role in the associated metabolic and hormonal disorders]]>
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