Asian Journal of Fertility, Endocrinology, and Reproduction
Vol. 1 No. 3 (2026): July 2026

A Comprehensive Systematic Review and Meta-Analysis: Unraveling the Efficacy of Soy Isoflavones in Managing Urinary Incontinence among Menopausal Women

Recavery Dwi Wulandari (Akademi Kebidanan Dharma Praja Bondowoso)
Sutrisno Sutrisno (Faculty of Medicine, Universitas Brawijaya/ Saiful Anwar General Hospital, Malang, East Java, Indonesia)



Article Info

Publish Date
26 Jul 2026

Abstract

Introduction: Urinary incontinence (UI) is a common and distressing condition that affects a significant proportion of menopausal women worldwide. Endogenous estrogen levels diminish during menopause, which can lead to weakening pelvic floor muscles and urogenital changes, and is a factor in the onset or exacerbation of UI symptoms. Previous studies have investigated the impact of soy isoflavones on various menopausal symptoms, including hot flashes and bone health, and their role in mitigating urinary incontinence remains an area of ongoing research. Methods:  This review is a systematic review. An inclusive, methodical search was conducted through PubMed, ScienceDirect, and Google Scholar to identify relevant studies. The selected studies were analyzed in Review Manager V.5.4 using a random-effects model to estimate the odds ratios with 95% confidence intervals. Results:  The discovery between the two studies showed that the soy isoflavone group achieved a significantly greater improvement than the placebo group, with a mean difference of 192.94 (95% CI 0.0, 2284.63; p < 0.00001). Nonetheless, it should be noted that the significance of the result is insubstantial due to the incompatible comparison groups across the studies. Conclusion:  This review on soy isoflavones and urinary incontinence in menopausal women discovered a positive tendency, but there is no statistical significance due to the conflicting studies.

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Journal Info

Abbrev

AJFER

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Social Sciences

Description

The Asian Journal of Fertility, Endocrinology, and Reproduction (AJFER), first launched in 2025, is a peer-reviewed and open-access scientific journal dedicated to advancing knowledge in the fields of fertility, endocrinology, and reproduction health published by the Pusat Pelatihan Profesional ...