Background: The risk of Occupational Diseases that often occurs in the informal industry is work stress. Work stress is not only caused by internal factors, but also caused by social factors from workers. This study aims to analyze and estimate the influence of social capital and other factors on work stress in informal industrial workers in the city of Surakarta. Subjects and Method: This study uses a cross-sectional study conducted on informal industry workers in Surakarta, Central Java, Indonesia, in April-May 2024. The number of study subjects was 210 people selected with a simple random sampling. The dependent variable was work stress. The independent variables were social capital, income, target achievement and capital borrowing status. Independent variable study data was taken using a questionnaire measuring tool, and for work stress using the Work Stress Questionnaire (WSQ). Data analysis in the form of multiple linear regression using Stata 13. Results: There was an effect of social capital (b= -1.38; 95% CI= -1.86 to -0.89; p<0.001), income (b= -0.56; 95% CI= -0.89 to -0.22; p=0.001), target achievement (b= -19.73; 95% CI= -23.59 to -15.89; p= 0.012) and capital borrowing status (b= 4.24; 95% CI = 0.95 to 7.52; p= 0.012) on work stress. Conclusion: Work stress is significantly affected by social capital, income, target achievement and borrowing status.
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