Type 2 Diabetes Mellitus requires continuous management. Health-Related Quality of Life (HRQoL) and medication adherence are important indicators of therapy success that are often affected by a decline in ongoing understanding. Analyze the effect of INTEGRA (Blood Glucose Telemonitoring Intervention) on HRQoL and medication adherence of Type 2 Diabetes Mellitus patients at the Cilacap Tengah I Community Health Center. This quasi-experimental pretest-posttest study with a control group involved 138 respondents (69 intervention, 69 control) selected by purposive sampling and simple randomization. The intervention group received the INTEGRA program for 12 weeks; the control group received standard care. HRQoL was measured using the WHOQOL-BREF and complemented by the Summary of Diabetes Self-Care Activity (SDSCA). Analysis used Mann-Whitney, Wilcoxon, and ANOVA. The intervention group showed an increase in SDSCA scores; the control did not change significantly. The WHOQOL-BREF intervention score increased, whereas the control remained stable. ANOVA showed INTEGRA increased confounding variables. INTEGRA effectively improves HRQoL and treatment adherence in patients with Type 2 Diabetes Mellitus. The program is recommended for services in primary health facilities.
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