<![CDATA[Parents' anxiety, especially mothers', regarding the effects of immunization remains a factor influencing the implementation of basic immunization in children. Pentabio immunization is a mandatory vaccine in the national immunization program to prevent diphtheria, pertussis, tetanus, hepatitis B, and Haemophilus influenzae type b. However, negative perceptions and anxiety regarding possible side effects after immunization can hinder the acceptance and implementation of immunization. This study aims to analyze the relationship between mothers' knowledge level regarding Pentabio immunization and their anxiety level regarding the effects of immunization in children at the Lemo 1 Community Health Center. This study used an observational analytical design with a cross-sectional approach. The sample consisted of 30 mothers selected using a purposive sampling technique. The research instruments included a 15-item knowledge questionnaire and a modified Hamilton anxiety scale. Data analysis was performed using the Chi-square test with an alternative Fisher's Exact Test at a significance level of 0.05. The results showed a significant relationship between mothers' knowledge level and anxiety (p = 0.048). Respondents with low knowledge levels tended to have higher anxiety levels compared to mothers with good knowledge. The conclusion of this study shows that maternal knowledge plays an important role in reducing anxiety regarding Pentabio immunization, so that structured education and effective health communication are needed in immunization services at primary health facilities.]]>
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