<![CDATA[Staphylococcus aureus is a major cause of nosocomial infections. Natural imunomodulatory agents are needed to strengthen immune responses. The Rajagaluh variety of durian peel contains flavonoids, saponins, tannins, triterpenoids, and alkaloids, which are potential imunomodulators. To analyze the imunomodulatory activity of durian peel extract on macrophage phagocytosis in S. aureus-infected Balb/C mice and determine the most effective dose. This experimental study used a post-test only control group design involving 30 male Balb/C mice divided into six groups (negative control, positive control, normal control, and three treatment groups receiving 200, 400, and 800 mg/kgBW of extract). The extract was administered orally, followed by S. aureus induction. Peritoneal fluid was collected to assess macrophage phagocytic activity. A significant increase in macrophage phagocytosis was observed in the 800 mg/kgBW treatment group, comparable to the standard immunostimulant Phyllanthus. Rajagaluh durian fruit leather has flavonoids, saponins, and tannins that play an active role. Durian fruit peel extract of the Rajagaluh variety demonstrates imunomodulatory activity by enhancing macrophage phagocytosis against Staphylococcus aureus. The most effective dose was 800 mg/kg BB.]]>
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