Thalassemia is a genetic blood disorder that remains a public health problem in Indonesia. Low public knowledge is one of the factors contributing to the suboptimal prevention of this disease. This study aims to analyze the level of community knowledge about thalassemia in Ujong Village, Samudera, Aceh Utara. This research employed a cross-sectional design with a quantitative approach. The sample consisted of 120 respondents selected using purposive sampling technique. The results showed that the majority of respondents had a moderate level of knowledge (52%), followed by low knowledge (33%) and high knowledge (15%). The conclusion of this study indicates that community knowledge still needs to be improved through continuous health education. In addition, public education about the importance of early detection and a deeper understanding of thalassemia will be an important step in more effective prevention efforts. This study provides important insights for thalassemia prevention efforts in areas with low knowledge.
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