Optimasi Konsentrasi Poloxamer 188 dalam Formulasi Gel Minyak Atsiri Daun Jeruk Purut (Citrus Hystrix Folium) serta Uji Efek Analgesik Secara In Vivo Pada Mencit (Mus Muculus)

Cut Suraiya Wahyuni Utami (STIKes Assyifa Aceh)
Santi Santi (STIKes Assyifa Aceh)
Erda Marniza (STIKes Assyifa Aceh)

Jurnal Ventilator: Jurnal Riset Ilmu Kesehatan dan Keperawatan
Vol. 4 No. 1 (2026): Jurnal Ventilator

Pain is the body's response to tissue damage that requires proper management. The use of synthetic analgesics often causes side effects, so safer natural alternatives are needed. Kaffir lime leaves (Citrus hystrix Folium) contain active compounds such as flavonoids, saponins, and tannins that have potential as analgesics. Topical gel preparations were chosen because they provide local effects and minimize systemic side effects. This study aimed to determine the effect of poloxamer 188 concentration variations on the physical characteristics and analgesic effects of kaffir lime leaf essential oil gel in mice using the hot plate test method.