Healthcare-associated infections (HAIs), particularly nosocomial infections, remain one of the most common health problems associated with healthcare services worldwide, affecting both developed and developing countries, especially in Intensive Care Units (ICUs). Patients in ICUs are highly vulnerable to infections due to invasive procedures, weakened immune systems, and prolonged hospitalization. Nurses play a critical role in preventing nosocomial infections because they have the most frequent and direct contact with patients. Therefore, adequate knowledge regarding infection prevention and control is essential to ensure the quality and safety of nursing care. This study aims to examine the relationship between nurses’ knowledge and efforts to prevent nosocomial infections in Intensive Care Units (ICUs). The study employed a literature review method by collecting and analyzing relevant scientific articles obtained through Google Scholar and PubMed databases. The selected articles were screened based on predetermined inclusion and exclusion criteria to ensure the relevance and quality of the reviewed literature. The findings consistently indicate a significant relationship between nurses’ knowledge and the implementation of nosocomial infection prevention measures in ICUs. Nurses with higher levels of knowledge demonstrate better compliance with infection prevention protocols, thereby reducing the risk of healthcare-associated infections. In conclusion, nurses’ knowledge is a key determinant of successful nosocomial infection prevention and should be continuously strengthened through education, training, and evidence-based clinical practice.
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