This study assessed HIV pre-exposure prophylaxis (PrEP) knowledge among men who have sex with men (MSM) in Yogyakarta, Indonesia, and examined differences in knowledge according to sociodemographic and behavioral characteristics. A cross-sectional survey was conducted among 92 MSM recruited from an HIV outreach foundation in Yogyakarta between May and July 2022. Participants completed a self-administered online questionnaire that included a 10-item PrEP knowledge scale. Data were analyzed using descriptive statistics, Pearson’s correlation, and an independent-samples t-test. This study found that PrEP knowledge among MSM in Yogyakarta was variable, with stronger knowledge observed for PrEP’s role in reducing HIV risk and the need for regular HIV testing, but persistent misconceptions regarding PrEP safety and effectiveness. Older age was positively associated with higher PrEP knowledge, while no significant differences in PrEP knowledge scores were observed by educational attainment, employment status, or awareness of partner HIV status. Homosexual MSM had significantly higher PrEP knowledge scores than bisexual MSM. These findings highlight the need for inclusive, community-based PrEP education strategies that address knowledge gaps, correct misconceptions, and ensure access to accurate HIV prevention information among diverse groups of MSM, particularly younger and bisexual MSM.
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