CORRELATION BETWEEN IFN-γ AND S-RBD SARS-COV-2 ANTIBODY LEVELS IN COVID-19 PATIENTS WITH ACUTE RESPIRATORY SYNDROME

Henny Fauziah (Department of Clinical Pathology, Faculty of Medicine and Health Science, Universitas Islam Negeri Alauddin Makassar/Department of Biomedical Science, Faculty of Medicine and Health Science, Universitas Islam Negeri Alauddin Makassar)
Tenri Esa (Department of Clinical Pathology, Faculty of Medicine, Universitas Hasanuddin, Makassar)
Uleng Bahrun (Department of Clinical Pathology, Faculty of Medicine, Universitas Hasanuddin, Makassar)
Mutmainnah (Department of Clinical Pathology, Faculty of Medicine, Universitas Hasanuddin, Makassar)
Alfian Zainuddin (Department of Public Health, Faculty of Medicine, Universitas Hasanuddin, Makassar)
Arif Santoso (Department of Pulmonology, Faculty of Medicine, Universitas Hasanuddin, Makassar)
Andi Irhamnia Sakinah (Department of Biology Education, Faculty of Tarbiyah and Teacher Training, Universitas Islam Negeri Alauddin Makassar/Department of Biomedical Science, Faculty of Medicine and Health Science, Universitas Islam Negeri Alauddin, Makassar)

Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Vol. 32 No. 2 (2026)

This study aimed to determine the correlation between interferon-gamma (IFN-γ) and S-RBD SARS-CoV-2 antibody levels in COVID-19 patients with acute respiratory syndrome. A cross-sectional study was conducted on 41 patients with non-severe syndrome of acute respiratory and 29 severe COVID-19 patients with severe syndrome of acute respiratory. IFN-γ levels were assessed using the enzyme-linked immunosorbent assay method. Antibody levels targeting the S-RBD were assessed using the Elecsys Anti SARS-CoV-2 S Cobas e411 ECLIA method. Significant difference (p <0,001) found between IFN-γ levels and the antibody levels in COVID-19 patients with non-severe and severe acute respiratory (p =0.238). However, no correlation was found between IFN-γ levels and antibody levels in patients classified as severe (p =0.208) or non-severe (p =0.081). No correlation between IFN-γ and the antibody levels in COVID-19 patients with severe acute respiratory syndrome and COVID-19 patients with non-severe, even though in non-severe patients, the IFN-γ levels are higher than in severe ones.