Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Vol. 32 No. 2 (2026)

THE CORRELATION BETWEEN NEUTROPHIL-LYMPHOCYTE RATIO (NLR) AND PROCALCITONIN WITH THE SEVERITY OF DIABETIC FOOT ULCER

Elsha Sinulingga (Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan)
Ricke Loesnihari (Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan/Department of Clinical Pathology, Adam Malik Hospital, Medan)
Sylvia Youvella (Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan/Department of Clinical Pathology, Adam Malik Hospital, Medan)
Nindia Sugiharto (Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan/Department of Clinical Pathology, Adam Malik Hospital, Medan)
Malayana Rahmita Nasution (Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan/Department of Clinical Pathology, Adam Malik Hospital, Medan)



Article Info

Publish Date
13 Mar 2026

Abstract

Diabetic foot ulcer (DFU) is a common complication in patients with diabetes mellitus (DM). A diabetic foot ulcer is a chronic wound below the ankle that lowers patient quality of life and raises morbidity and mortality rates. The severity of DFU can be evaluated using the Meggitt-Wagner classification. Wagner offers six grades, “0”is the least severe and“V”is the most severe. The neutrophil-to-lymphocyte ratio (NLR) is a basic inflammatory marker. Procalcitonin is an amino acid protein precursor of the hormone calcitonin secreted by thyroid C cells and other body cells. To diagnose diabetic foot infections, procalcitonin is crucial. From February 2024 to May 2024, type 2 DM patients with DFU at H. Adam Malik General Hospital in Medan who met the inclusion and exclusion criteria were enrolled in analytical cross-sectional study. Simultaneous blood samples were collected for procalcitonin measurement and analysis of neutrophil and lymphocyte counts. The correlation between NLR and DFU severity is weak and not significant (p = 0.278; r = 0.156). The median NLR value is 7.7 (1.6 - 32.03). A strong, statistically significant positive correlation was observed between procalcitonin levels and the severity of diabetic foot ulcer (DFU) (r = 0.651; p <0.05). The median procalcitonin value is 0.5 (0.03-4.7). There was a positive correlation between procalcitonin and DFU severity. There was no correlation between NLR and DFU severity.

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Journal Info

Abbrev

patologi

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

Description

Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of ...