<![CDATA[Patients with liver cirrhosis are at risk of developing coagulopathy, particularly bleeding complications. Conventional screening tests, such as Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT), measure only clot formation time, offering limited insight into the comprehensive coagulation dynamics. Clot Wave Analysis (CWA), obtained from photo-optical coagulation analyzers, monitors real-time changes in transmitted light during fibrin formation, providing deeper insights into the coagulation process. Although earlier studies demonstrated CWA's utility in detecting coagulopathy in cirrhotic patients, its role in individuals presenting with normal PT and APTT values, or in early-stage cirrhosis, remains insufficiently explored. This preliminary cross-sectional study aimed to evaluate clot waveform characteristics using CWA in cirrhotic patients exhibiting normal coagulation profiles for the early identification of coagulation abnormalities. Waveforms from PT and APTT assays were qualitatively analyzed for patterns and quantitatively assessed using parameters including maximum velocity (Min 1, dT/dt), maximum acceleration (Min 2), maximum deceleration (Max 2, d²T/dt²), and maximum clot density (Delta, dH). This study enrolled 50 participants (25 cirrhotic patients and 25 healthy controls) with normal PT and APTT values. Qualitatively, cirrhotic patients exhibited flatter waveform slopes compared to controls. Quantitatively, significant reductions were observed in Min 1, Max 2, and Delta in CWA-PT and all parameters in CWA-APTT. CWA shows potential in detecting coagulopathy in cirrhotic patients with normal PT and APTT. Further studies are needed to establish standardized CWA reference values for clinical applications.]]>
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