Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi)
Vol 10 No 5 (2026): October 2026 (In progress)

Quantifying Target Leakage in SEER Breast Cancer Mortality Prediction

Sestri Novia Rizki (Universitas Media Nusantara Citra)
Vani Maharani Nasution (Universitas Jakarta Internasional)
Eko Amri Jaya (Universitas Media Nusantara Citra)
Verra Budhi Lestari (Universitas Media Nusantara Citra)
Elfina Maulid (Universitas Media Nusantara Citra)



Article Info

Publish Date
07 Oct 2026

Abstract

Recent machine learning studies on the SEER Breast Cancer dataset report 95–98% accuracy (2022–2025), but their methods are rarely examined. Because the dataset is imbalanced (84.7% Alive), accuracy alone is a poor discrimination metric — a trivial always-Alive classifier scores near 85% — so this audit quantifies leakage inflation on ROC-AUC, computed identically across 12 models. We measure how much performance stems from target leakage via Survival Months, which encodes retrospective survival time unavailable at prediction. Undetected, such leakage could lead clinicians to overtrust a model's risk estimates, risking inappropriate care decisions. We train 12 models under three conditions: a) naïve, with Survival Months and a non-stratified split; b) leakage-free with stratified evaluation; and c) fixed-horizon (36- and 60-month) binary mortality, excluding censored cases. Under Condition A, the best ROC-AUC is 0.889 (accuracy 0.899). Removing leakage yields a consistent AUC ceiling of 0.74–0.77 across all 12 models — an inflation of +0.07 to +0.20 AUC points. SHAP shows Survival Months dominates feature importance by 3.0–4.3× under leakage; imbalance-handling methods (BorderlineSMOTE, class weighting) raise minority-class F1 but lower mean Brier Skill Score to −0.585 and −0.597. The contribution is the audit methodology itself — a reusable protocol for detecting leakage-driven inflation in registry-based clinical prediction.

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Journal Info

Abbrev

RESTI

Publisher

Subject

Computer Science & IT Engineering

Description

Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi) dimaksudkan sebagai media kajian ilmiah hasil penelitian, pemikiran dan kajian analisis-kritis mengenai penelitian Rekayasa Sistem, Teknik Informatika/Teknologi Informasi, Manajemen Informatika dan Sistem Informasi. Sebagai bagian dari semangat ...