The Early Warning and Response System (EWARS), known in Indonesia as Sistem Kewaspadaan Dini dan Respons (SKDR), is a surveillance system used to detect and respond to disease events at an early stage. The successful implementation of SKDR at the primary healthcare level is supported by healthcare workers’ characteristics and the availability of supporting resources. This study aimed to describe the success of SKDR implementation in public health centers (Puskesmas) across Palembang City and the factors supporting its implementation. This study employed a quantitative method with a descriptive design. The factors examined included age, gender, educational attainment, functional position, length of employment, experience as SKDR personnel, multiple job responsibilities, and supporting resources, including the availability of equipment, network access, SKDR guidelines, and training. The results showed that the SKDR success indicators, including report completeness, reporting timeliness, and alert response, each reached 100%. Regarding supporting factors, most personnel were aged 30–44 years, accounting for 27 respondents (64.3%). A total of 19 personnel (45.2%) reported that supporting facilities and infrastructure were available, while 23 personnel (54.8%) reported that they were not adequately available. Most personnel had more than two concurrent responsibilities, totaling 36 personnel (85.7%). The implementation of SKDR in public health centers across Palembang City had achieved the established success indicators. However, strengthening supporting resources and managing personnel workload are still needed to maintain the successful implementation of SKDR.
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