<![CDATA[Introduction: Vitamin C (ascorbic acid) plays an important role in supporting the immune system; however, it has low stability and is prone to degradation during distribution and storage, which may affect product quality. Objective: This study aimed to determine the content and content uniformity of vitamin C in four commercial generic tablet brands in Indonesia as a quality control effort to ensure compliance with established standards. Methods: Vitamin C content determination was performed using the 2,6-Dichlorophenol Indophenol (DCPIP) titration method, which was verified through precision and accuracy in four tablet brands, followed by a content consistency among tablets. Result: The DCPIP titration method showed good precision, with an %RSD value of 0.81% (criterion <2%), and good accuracy with %recovery ranging from 98.17% to 99.14% (criterion 98.0% to 102.0%). The vitamin C content in the four brands range from 93.63% to 95.12% of the labeled claim, meeting the required range of 90.0% to 110.0%. The Acceptance Value (AV) obtained from the content uniformity test ranged from 5.49 to 6.11, below the acceptance limit (L1<15.0), indicating that all four brands met the quality requirements. Conclusion: The DCPIP titration method demonstrated food precision and accuracy, making it reliable for vitamin C content determination. All four commercial generic tablet brands tested met both content and content uniformity requirements, indicating good quality and compliance with the claims started on label.]]>
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