<![CDATA[Pain is a health problem that can be managed with analgesic agents. Red gedi leaves (Abelmoschus manihot L.) contain secondary metabolites with potential biological activity. This study aimed to determine the analgesic effectiveness of 96% ethanol extract of red gedi leaves in mice induced with 1% acetic acid. A laboratory experimental study with a completely randomized design was conducted in 2026 using 15 male mice divided into five groups: negative control (Na-CMC), positive control (ibuprofen), and extract doses of 100, 200, and 400 mg/kg body weight. Analgesic activity was evaluated using the writhing test by recording the cumulative number of writhes and calculating the percentage inhibition. The mean numbers of writhes were 66.33, 24.00, 51.33, 43.00, and 28.00 for the negative control, positive control, and extract doses of 100, 200, and 400 mg/kg, respectively. The inhibition percentages of the extract were 22.61%, 35.17%, and 57.79%. One-way ANOVA showed a significant difference among groups (p<0.05). Tukey HSD showed that the 400 mg/kg dose did not differ significantly from ibuprofen (p=0.190). The extract contained alkaloids, flavonoids, steroids, saponins, and tannins. The 400 mg/kg dose showed the highest analgesic response among the tested extract doses.]]>
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