<![CDATA[Intestinal protozoan infections, particularly Entamoeba histolytica and Giardia lamblia, remain important health concerns associated with sanitation, water safety, and environmental conditions. Conventional treatment commonly relies on nitroimidazole drugs; however, adverse effects and reports of reduced drug sensitivity encourage the exploration of natural antiparasitic alternatives. Indonesia possesses diverse medicinal plants with potential bioactive compounds, including turmeric (Curcuma longa), betel leaf (Piper betle), and moringa (Moringa oleifera). This article aims to review the potential of bioactive compounds from these plants against intestinal protozoa, particularly E. histolytica and G. lamblia. A literature review was conducted using scientific publications from 2016–2026, supplemented by earlier studies when relevant. Curcumin showed the strongest evidence against both protozoa, including inhibition of growth and viability, disruption of cellular integrity, and suppression of virulence and invasion. Piper betle demonstrated antigiardial potential, although evidence against E. histolytica remains limited. Moringa oleifera showed activity against G. lamblia in diverse experimental models, while evidence against E. histolytica remains limited. Further studies are needed to confirm efficacy, safety, active compounds, and molecular mechanisms.]]>
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