<![CDATA[Bakground: Pineapple core (Ananas comosus) contains bromelain enzyme, which is known to remove dead skin tissue and promote the formation of new tissue. Pineapple fruit and core are also rich in bioactive compounds with potential pharmacological effects. In the oral cavity, it is beneficial in increasing salivary flow. Objective: This study aimed to analyze the toxicity and histological effects of pineapple core extract (Ananas comosus) in male Wistar rats (Rattus norvegicus) using control and treatment groups. Methods: This experimental study used 30 male Wistar rats (Rattus norvegicus), which were administered pineapple core extract supplementation for 14 days. The feed formulation contained pineapple core extract at concentrations of 75% and 90%, with doses ranging from 5,000 mg/kg body weight (BW) to 10,000 mg/kg BW. Histological examination of rat liver tissue was performed at the end of the study. Results: Observation of the control group demonstrated normal liver histology, in which hepatocytes were radially arranged within the hepatic lobules. Similar findings were observed in treatment group (K1), where most hepatocytes appeared normal, with only mild degeneration and necrosis, as well as congestion in the sinusoidal area.Conclusion: Pineapple core extract did not demonstrate toxic effects up to a dose of 10,000 mg/kg BW, although minimal histological alterations in liver tissue were observed.]]>
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