<![CDATA[Background: The gingival depigmentation procedure can result in extensive open wounds, patient discomfort, and an increased risk of infection. A Non-eugenol Periodontal Pack (NEP) is a common material to protect wounds from mechanical trauma and increase patient’s comfort but does not promote healing. Liquid Platelet-rich Fibrin (PRF) is clinically proven to regenerate tissues, however, its effectiveness following gingival depigmentation remains limited. Purpose: This study aims to compare post-gingival depigmentation outcomes after application of liquid PRF and NEP. Methods: Clinical trials were conducted on five healthy subjects who met the inclusion and exclusion criteria. Gingival depigmentation was performed in the anterior region using a scalpel, followed by the application of NEP (left side) and PRF (right side). Healing Index (HI), pain perception by Visual Analog Scale (VAS), and Wound Healing Score (WHS) were measured on days 5, 7, and then statistically analyzed with a significance value of p<0.05. Results: The HI on day 5 of the liquid PRF group was higher than NEP (p<0.05), however, the HI on day 7, VAS on days 5 and 7, and WHS on days 5 and 7 were not significantly different (p>0.05). Conclusion: Liquid PRF accelerates wound healing faster than NEP. Despite this difference, both materials. deliver similar results regarding patient comfort and epithelialization.]]>
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