JPK: Jurnal Proteksi Kesehatan
Vol 15 No 1 (2026): JPK: Jurnal Proteksi Kesehatan

Evaluation of Anticoagulant Therapy Based on Therapeutic Target Achievement and Dose Appropriateness in Patients Receiving Anticoagulants

Isna Wardaniati (Universitas Abdurrab)
Diana Nazara (Universitas Abdurrab, Pekanbaru, Indonesia)



Article Info

Publish Date
22 Sep 2026

Abstract

Deep Vein Thromboembolism (DVT) is a form of venous thromboembolism requiring anticoagulant therapy to prevent complications. Treatment effectiveness is assessed through therapeutic target achievement based on Activated Partial Thromboplastin Time (APTT) for heparin, Prothrombin Time/International Normalized Ratio (PT/INR) for warfarin, and dose appropriateness for other anticoagulants. This study aimed to evaluate therapeutic target achievement and dose appropriateness in DVT patients receiving anticoagulant therapy at the Inpatient Unit of X Hospital, Pekanbaru, in 2024. This descriptive observational study used a cross-sectional approach with retrospective medical record data. A total of 45 patients were selected using total sampling. Heparin was the most frequently used anticoagulant (22 patients; 48.89%), followed by warfarin (10; 22.22%), rivaroxaban (5; 11.11%), fondaparinux (5; 11.11%), and enoxaparin (3; 6.67%). Therapeutic targets were achieved by 27 patients (84.38%), while 5 patients (15.62%) did not achieve the target. Regarding dose appropriateness, 8 patients (61.53%) received appropriate doses, while 5 patients (38.46%) received inappropriate doses. In conclusion, most DVT patients achieved therapeutic targets and received appropriate doses. Monitoring APTT, PT/INR, and dose appropriateness remains important to support the effectiveness and safety of anticoagulant therapy.

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