<![CDATA[Photoaging is a form of skin aging caused by chronic exposure to ultraviolet (UV) radiation, which induces oxidative stress, inflammation, and collagen degradation. Mesenchymal stem cell-derived exosomes (MSC-Exos) have demonstrated potential to support skin regeneration through their bioactive cargo, which influences cellular proliferation, collagen synthesis, antioxidant responses, and inflammatory regulation. This systematic literature review aimed to analyze the role of MSC-Exos in skin regeneration associated with photoaging. The reviewed literature indicates that MSC-Exos can enhance fibroblast activity, promote extracellular matrix repair, reduce matrix metalloproteinase expression, and regulate molecular pathways involved in skin regeneration. In vitro and in vivo studies have shown relatively consistent evidence supporting the anti-photoaging and regenerative effects of MSC-Exos. However, variations in mesenchymal stem cell sources, exosome isolation and characterization methods, dosages, administration routes, and experimental models have limited direct comparability among studies. Although preclinical findings are promising, further clinical research using standardized protocols is required to establish the safety, efficacy, and translational potential of MSC-Exos for photoaging treatment.]]>
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