<![CDATA[Dental caries is a common oral health problem primarily caused by the bacterium Streptococcus mutans and the fungus Candida albicans. The use of chemical antimicrobial agents may cause adverse effects, highlighting the need for safer natural alternatives such as Lilium (lily) essential oil. This study aimed to evaluate the inhibitory effect of Lilium essential oil against Streptococcus mutans and Candida albicans in vitro using the well diffusion method. A laboratory experimental design was conducted using essential oil concentrations of 10%, 15%, and 20%. The evaluated parameters included phytochemical screening, physical quality, and inhibition zone diameter. The results showed that Lilium essential oil contained alkaloids, flavonoids, phenols, and terpenoids and exhibited good physical quality. The inhibition zones against Streptococcus mutans were 1.97 ± 0.38 mm, 5.35 ± 2.06 mm, and 11.40 ± 0.91 mm, while those against Candida albicans were 4.30 ± 0.86 mm, 7.35 ± 1.20 mm, and 17.40 ± 0.75 mm at 10%, 15%, and 20%, respectively. Statistical analysis showed significant differences among concentrations (p < 0.05), with 20% demonstrating the strongest antimicrobial activity. ABSTRAK Karies gigi merupakan masalah kesehatan mulut yang banyak disebabkan oleh bakteri Streptococcus mutans dan jamur Candida albicans. Penggunaan bahan kimia sebagai antimikroba berpotensi menimbulkan efek samping, sehingga diperlukan alternatif alami, salah satunya minyak atsiri bunga lily (Lilium). Penelitian ini bertujuan menganalisis efektivitas minyak atsiri bunga lily dalam menghambat pertumbuhan Streptococcus mutans dan Candida albicans secara in vitro menggunakan metode well diffusion. Penelitian eksperimen laboratorium ini menggunakan konsentrasi 10%, 15%, dan 20%. Parameter yang diamati meliputi skrining fitokimia, mutu fisik minyak atsiri, dan diameter zona hambat. Hasil menunjukkan minyak atsiri bunga lily mengandung alkaloid, flavonoid, fenol, dan terpenoid serta memiliki mutu fisik yang baik. Aktivitas antibakteri terhadap Streptococcus mutans menghasilkan zona hambat 1,97 ± 0,38 mm; 5,35 ± 2,06 mm; dan 11,40 ± 0,91 mm, sedangkan aktivitas antifungi terhadap Candida albicans sebesar 4,30 ± 0,86 mm; 7,35 ± 1,20 mm; dan 17,40 ± 0,75 mm pada konsentrasi 10%, 15%, dan 20%. Analisis statistik menunjukkan perbedaan yang signifikan (p < 0,05), dengan konsentrasi 20% sebagai yang paling efektif menghambat pertumbuhan kedua mikroorganisme.]]>
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