<![CDATA[This study aimed to analyze the effect of anti-tuberculosis drugs (OAT) on hemoglobin and hematocrit levels in patients with drug-resistant tuberculosis (DR-TB) who received treatment at Ibnu Sina Regional General Hospital, Gresik Regency, with data collected from patients undergoing treatment between 2022 and 2025. The background of this study is based on the high incidence of DR-TB cases in Indonesia and the limited number of studies focusing on this specific topic. The method used in this study was a retrospective cohort design. A total of 69 subjects were included using a total sampling technique. Data were collected from medical records and analyzed using ANOVA and Friedman tests with a significance level of p < 0.05. The results showed that there was a significant effect of DR-TB anti-tuberculosis drug treatment on hemoglobin and hematocrit levels. However, in the 6-month treatment regimen (BPaL or BPaL/M), no significant effect was observed. In conclusion, anti-tuberculosis drugs for DR-TB have a significant effect on hemoglobin and hematocrit levels in patients undergoing treatment at Ibnu Sina Regional General Hospital, Gresik Regency. This study is expected to contribute to clinical practice and serve as a basis for future research.]]>
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