<![CDATA[Colorectal cancer is one of the most common malignancies worldwide, with high incidence and mortality rates. Surgery remains the main treatment; however, postoperative complications, particularly surgical site infections and anastomotic leakage, remain common. Malnutrition increases the risk of these complications. Perioperative immunonutrition containing arginine, glutamine, omega-3 fatty acids, nucleotides, and antioxidants may enhance immune responses, reduce inflammation, and accelerate tissue healing. This study aimed to evaluate the impact of perioperative immunonutrition on reducing surgical site infections and anastomotic leakage in patients with colorectal cancer. This study employed a literature review using a descriptive-narrative approach. Data were obtained from scientific articles published within the last five years through PubMed, Google Scholar, ScienceDirect, Springer, and Cochrane databases. The literature included systematic reviews, meta-analyses, randomized controlled trials, and observational studies relevant to the topic. Results showed that most studies reported clinical benefits of perioperative immunonutrition, including reduced surgical site infections, fewer postoperative infectious complications, improved immune responses, decreased inflammatory markers, and faster recovery. Several studies also indicated a tendency toward reduced anastomotic leakage, particularly in malnourished or high-risk patients, although findings varied. In conclusion, perioperative immunonutrition may improve postoperative outcomes, particularly by reducing surgical site infections and supporting healing. However, evidence regarding anastomotic leakage remains inconsistent, requiring further robust studies.]]>
Copyrights © 2026
