Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat
Vol. 9 No. 2 (2025): Desember

UJI STABILITAS FISIK DAN PENETAPAN KADAR FENOLIK SEDIAAN KRIM EKSTRAK ETANOL HERBA BANDOTAN (Ageratum conyzoides L.)

Disa Andriani (STIKES Nasional)
Salva Fellia Rahmawati (Sekolah Tinggi Ilmu Kesehatan Nasional)
Nastiti Utami (Sekolah Tinggi Ilmu Kesehatan Nasional)



Article Info

Publish Date
31 Dec 2025

Abstract

Bandotan (Ageratum conyzoides L.) is a wild plant that grows quickly and thrives in various types of soil. Bandotan contains various metabolite compounds, one of which is phenolic compounds. This study aims to obtain a stable cream preparation by varying the concentration of stearic acid and triethanolamine (TEA) to obtain an optimal formulation. The cream was formulated with varying concentrations of stearic acid of 18%, 19%, and 20%, and TEA of 3%, 2.5%, and 2%. Stability evaluation was carried out using the cycling test method which includes organoleptic tests, homogeneity, pH, adhesiveness, spreadability and viscosity. The results showed that the ethanol extract of bandotan herb containing phenolic compounds with all variations of stearic acid and TEA concentrations met the test requirements and did not show differences in organoleptic, homogeneity, pH, adhesiveness, spreadability and viscosity. Statistical test results indicate that the cream preparation is physically stable, as there was no significant difference between the cream preparation before and after the cycling test, but there was a significant decrease in phenolic content.

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Journal Info

Abbrev

jurnal_farmasindo

Publisher

Subject

Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

Description

The journal includes various fields of pharmaceuticals sciences such as: Pharmacy, Pharmacokinetics, Community and Clinical Pharmacy, Medical, Alternative medicines, Synthetic Organic Chemistry, Organic Chemistry of Natural Material, Biochemistry, Chemical Analysis, Microbiology, Tissue Culture, ...