Gambaran Kadar High Sensivitas C-Reactive Protein (HsCRP) Pada Penderita Diabetes Melitus

Muslina Muslina (Poltekkes Kemenkes Jambi)
Agraini Agraini (Poltekkes Kemenkes Jambi)
Sri Ujiani (Poltekkes Kemenkes Lampung)
Lolita Lolita (Universitas Ahmad Dahlann)

Jurnal Ners
Vol. 10 No. 4 (2026): OKTOBER 2026

Diabetes melitus (DM) merupakan penyakit metabolik yang dapat menyebabkan peradangan kronis, sedangkan tuberkulosis (TB) dapat meningkatkan respons peradangan pada penderita DM. Penelitian ini bertujuan mengetahui perbedaan kadar high-sensitivity C-reactive protein (hs-CRP) pada penderita DM dan DM-TB serta hubungan lama menderita DM dengan kadar hs-CRP. Penelitian menggunakan desain cross-sectional dengan pendekatan deskriptif terhadap 90 responden, terdiri atas 45 penderita DM dan 45 penderita DM-TB. Pemeriksaan hs-CRP dilakukan di Laboratorium Imunoserologi Poltekkes Kemenkes Jambi pada April–Juni 2026. Analisis data menggunakan analisis univariat, uji Mann-Whitney, dan uji korelasi Spearman. Hasil penelitian menunjukkan median kadar hs-CRP kelompok DM sebesar 2,50 mg/dL, sedangkan kelompok DM-TB sebesar 21,0 mg/dL. Uji Mann-Whitney menunjukkan perbedaan signifikan antara kedua kelompok (p < 0,001). Uji Spearman menunjukkan tidak terdapat hubungan signifikan antara lama menderita DM dan kadar hs-CRP pada kelompok DM (r = 0,018; p = 0,905) maupun DM-TB (r = 0,159; p = 0,297). Disimpulkan bahwa kadar hs-CRP pada penderita DM-TB lebih tinggi dibandingkan penderita DM tanpa TB, sedangkan lama menderita DM tidak berhubungan signifikan dengan kadar hs-CRP. Kata kunci: Diabetes melitus, tuberkulosis, hs-CRP, peradangan, lama menderita Diabetes Melitus. Abstract Diabetes mellitus (DM) is a metabolic disease that can cause chronic inflammation, while tuberculosis (TB) may further increase the inflammatory response in patients with DM. This study aimed to determine the difference in high-sensitivity C-reactive protein (hs-CRP) levels between patients with DM and those with DM and TB (DM-TB), as well as to determine the relationship between the duration of DM and hs-CRP levels. This study employed a cross-sectional design with a descriptive approach. The sample consisted of 90 respondents, comprising 45 patients with DM and 45 patients with DM-TB who met the inclusion and exclusion criteria. hs-CRP levels were measured at the Immunoserology Laboratory of Poltekkes Kemenkes Jambi from April to June 2026. Data were analyzed using univariate analysis, the Mann-Whitney test to determine differences in hs-CRP levels, and the Spearman correlation test to assess the relationship between DM duration and hs-CRP levels. The results showed that the median hs-CRP level was 2.50 mg/dL in the DM group and 21.0 mg/dL in the DM-TB group. The Mann-Whitney test demonstrated a statistically significant difference in hs-CRP levels between the DM and DM-TB groups (p < 0.001). The Spearman correlation test showed no significant relationship between the duration of DM and hs-CRP levels in either the DM group (r = 0.018; p = 0.905) or the DM-TB group (r = 0.159; p = 0.297). In conclusion, hs-CRP levels were significantly higher in patients with DM-TB than in those with DM alone, whereas the duration of DM was not significantly associated with hs-CRP levels. Keywords: Diabetes Mellitus, Tuberculosis, hs-CRP, inflammation, duration of diabetes mellitus.