Background: Blood pressure measurements are performed periodically depending on the patient's condition. This can cause discomfort and even injury. Objective: The purpose of this study was to develop a preventive dressing tool used in continuous blood pressure measurement with a bedside monitor to prevent MDRPI in critically ill patients. Methods: The research method was Research and Development with 3 stages. The first stage was observation, interviews, literature studies, and FGDs with 8 critically ill nurses, one electromedical staff member and one facilities staff member. The second stage was a validity and usability test using 3 experts (intensivist, intensive care cardiologist, dermatologist) and 30 healthy respondents. The third stage was a quasi-experimental pretest-posttest design with a control group with 120 patients (60 in the intervention group, 60 in the control group) using consecutive allocation, sampling was conducted sequentially across the control and intervention groups. Data analysis used chi-square, fisher, kolmogorov-smirnov. Statistical significance was set at α = 0.05. Results: The developed dressing achieved a Content Validity Index (CVI) of 0.90 and a System Usability Scale (SUS) score of 83.08. The intervention significantly improved patient comfort and reduced pain (p = 0.043), but its effect on redness was not statistically significant (p = 0.122). No allergic reactions were observed in either group. Conclusion: The developed preventive dressing demonstrated good validity and usability and significantly improved patient comfort while reducing pain. Further evaluation is needed before its application in pediatric patients.
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