<![CDATA[Background: Diabetes-related foot ulcer (DRFU) is a serious complication of diabetes mellitus associated with delayed wound healing. Therapeutic ultrasound may provide additional benefits alongside standard wound care and controlled dietary management. Objective: This study aimed to examine the effectiveness of adjunctive therapeutic ultrasound in reducing wound surface area in patients with DRFU. Methods: This quasi-experimental, non-randomized pre-test–post-test controlled study was conducted at Kartasura Primary Health Care Center from February to May 2026. Using purposive sampling, 25 patients aged 30–65 years with Wagner grade 1–2 diabetes-related foot ulcers (DRFU) were enrolled and allocated to an ultrasound group (n = 13) or a control group (n = 12). The intervention lasted four weeks. Wound surface area was measured at baseline and post-intervention using manual planimetry by an independent, blinded assessor. Baseline-adjusted analysis of covariance (ANCOVA) was used for the primary between-group comparison. Results: Both groups showed significant reductions in wound surface area (p < 0.0001). ANCOVA showed a significantly lower adjusted post-intervention wound area in the ultrasound group than in the control group (5.619 vs. 6.355 cm²; mean difference = 0.736 cm²; p = 0.015; partial η² = 0.240). However, the unadjusted between-group difference in wound area reduction was not significant (2.12 vs. 1.37 cm²; p = 0.159). Conclusion: Adjunctive therapeutic ultrasound was associated with a lower adjusted post-intervention wound area. However, the non-significant unadjusted comparison and the study's non-randomized design and small sample warrant cautious interpretation.]]>
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