<![CDATA[Emesis gravidarum is an obstetric complaint experienced by up to 80% of pregnant women and may progress into a life-threatening condition if left unmanaged. This study aims to analyze the effectiveness of lime (Citrus aurantifolia) infusion drink in reducing nausea and vomiting among pregnant women at Sofifi Hospital. A quantitative approach with a pre-experimental one group pretest-posttest design was applied to 30 respondents selected through purposive sampling. Measurements were conducted using the Pregnancy-Unique Quantification of Emesis (PUQE-24) instrument before and after three days of intervention. Results revealed that 86.7% of respondents demonstrated effective reduction in nausea and vomiting. The Wilcoxon Signed Ranks Test yielded Z = −4.810 with p = 0.000, confirming a statistically significant difference between pre- and post-intervention conditions. Bioactive compounds including flavonoids and D-limonene in lime were found to inhibit emetic responses through neurochemical pathways. Lime infusion is recommended as an evidence-based complementary intervention within midwifery care protocols.]]>
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