Red Jeringau (Acorus sp.) has been used empirically to cure diseases in West Kalimantan. This study aims to examine the antiinflammatory effects and optimum dose of ethanol extract of Red Jeringau rhizomes in Wistar male rats. The samples were divided into five groups, positive control group was given diclofenac sodium, negative control group was given CMC-Na 1%, and the extract groups were given 225 mg/bw, 450 mg/bw and 675 mg/bw ethanol extract of red Jeringau rhizomes. The test was on artificial inflammation in left foot of Wistar male rats induced with carrageenan 2%. AUC values were used calculate the antiinflammatory effects on each group compared to control group. Data were analyzed by one-way ANOVA and LSD test. The results showed that ethanol extract of Red Jeringau rhizomes has antiinflammatory activity and the optimum dose was 450 mg/kgBB with antiinflammatory percentage 34,20%.
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